Angewandte Chemie International Edition

Saikat Das, Constantin G. Daniliuc, Armido Studer

Indolylboron ate complexes readily generated from 2-lithioindoles and boronic esters underwent multicomponent dearomative coupling with D-A cyclopropanes and alkyl halides in the presence of Sc(OTf)3 as a catalyst. The reactions proceeded with complete diastereoselectivity and excellent stereospecificity to provide indolines containing three contiguous stereocenters. The valuable boronic ester moiety remains in the product and allows for subsequent functionalization.

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A four-component coupling of 2-lithioindoles, boronic esters, donor–acceptor cyclopropanes, and alkyl halides in the presence of the Lewis acid catalyst Sc(OTf)3 provided indolines with three contiguous stereocenters, including a quaternary center, with complete diastereoselectivity and stereospecificity (see scheme). The valuable boronic ester moiety remaining in the products allows for subsequent functionalization.

Yasuaki Kawaguchi, Kenya Yabushita, Chisato Mukai
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The combination of an allenyne with an additional π-component in the presence of a rhodium(I) catalyst constitutes a new approach for ring closure. In their Communication (DOI: 10.1002/anie.201713096), C. Mukai and co-workers report a rhodium(I)-catalyzed cycloisomerization of homopropargylallene-alkynes into six/five/five tricyclic frameworks that proceeds through migration of the alkyne moiety of the homopropargyl substituent. The cover picture shows the famous “Tsuzumi Gate” of Kanazawa station.

Zhang Luo, Bing Liu
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How can liquid droplets be used for the synthesis of anisotropic colloids? In their Communication (DOI: 10.1002/anie.201800587), B. Liu and Z. Luo report a template strategy for the synthesis of anisotropic colloids with shapes that can be continuously tuned from discs to spheres to theta shapes to dumbbells. This method is based on creating structured shape-tunable droplets from patchy colloidal discs and using these droplets as templates.

Ilaria Degano, Francesca Modugno, Ilaria Bonaduce, Erika Ribechini, Maria Perla Colombini

The molecular characterization of organic materials in samples from artworks and historical objects traditionally entailed qualitative and quantitative analyses by HPLC and GC. Today innovative approaches based on analytical pyrolysis enable samples to be analysed without any chemical pre-treatment. Pyrolysis, which is often considered as a screening technique, shows previously unexplored potential thanks to recent instrumental developments. Organic materials that are macromolecular in nature, or undergo polymerization upon curing and ageing can now be better investigated. Most constituents of paint layers and archaeological organic substances contain major insoluble and chemically non-hydrolysable fractions that are inaccessible to GC or HPLC. To date, molecular scientific investigations of the organic constituents of artworks and historical objects have mostly focused on the minor constituents of the sample. This review presents recent advances in the qualitative and semi-quantitative analyses of organic materials in heritage objects based on analytical pyrolysis coupled with mass spectrometry.

Helma Wennemers, Carlotta Foletti, Rolf Kramer, Harald Mauser, Urs Jenal, Konrad Bleicher

c di GMP is an attractive target in the fight against bacterial infections as it is a near ubiquitous second messenger that regulates important cellular processes, including biofilm formation and virulence of pathogens. The screening of a combinatorial peptide library enabled the identification of the proline-rich tetrapeptide Gup-Gup-Nap-Arg that binds c di GMP in water with selectivity over other nucleotides. Computational and CD spectroscopic studies provided a binding mode of the complex and enabled the design of a pentapeptide with even higher binding strength towards c di GMP. Biological studies showed that the tetrapeptide inhibits biofilm growth of the opportunistic pathogen P. aeruginosa.

Journal of Physical Chemistry C

Sharada Govinda, Bhushan P. Kore, Diptikanta Swain, Akmal Hossain, Chandan De, Tayur N. Guru Row and D. D. Sarma

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The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.8b00602
Shipra Jain, Jyoti Shah, S. R. Dhakate, Govind Gupta, C. Sharma and R. K. Kotnala

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The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.7b12561

Journal of Physical Chemistry A

Maria Gabriella Chiariello and Nadia Rega

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The Journal of Physical Chemistry ADOI: 10.1021/acs.jpca.7b12371

Journal of Physical Chemistry B

Zhaoqian Su, Gopal Ravindhran and Cristiano L. Dias

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The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.7b11847
Brian Doherty, Xiang Zhong and Orlando Acevedo

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The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.7b11996


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