Journals

Angewandte Chemie International Edition

Andreas Eichinger, Irmgard Neumaier, Michael Pschenitza, Reinhard Nießner, Dietmar Knopp, Arne Skerra

Benzo[a]pyrene, produced during the combustion of organic material, is an abundant noxious pollutant because of its carcinogenic metabolic degradation products. The high affinity (KD ≈ 3 nM) monoclonal antibody 22F12 allows facile bioanalytical quantification of benzo[a]pyrene even in complex matrices. Here, we report its functional and X-ray crystallographic analysis in complex with 3-hydroxybenzo[a]pyrene after cloning of the V-genes and production as a recombinant Fab fragment. The polycyclic aromatic hydrocarbon is bound in a deep pocket beween the light and heavy chains surrounded mainly by aromatic and aliphatic amino acid side chains. Interestingly, the hapten-antibody interface is less densely packed than expected and reveals also polar, H-bond-like interactions with the polycyclic aromatic π-electron system which may allow the antibody to maintain a large, predominantly hydrophobic binding site in an aqueous environment while providing sufficient complementarity to its ligand.

Liying Zhang, Tingting Cui, Xiao Cao, Chengji Zhao, Quan Chen, Lixin Wu, Haolong Li

A facile and electrostatically-driven approach has been developed to prepare bicontinuous polymer nanocomposites, through the polyoxometalate (POM) macroion-induced phase transition of PS-b-P2VP from an initial lamellar phase to a stable bicontinuous phase. The multi-charged POMs can electrostatically crosslink P2VP blocks and lead to bicontinuous phases in which the POM-hybrid conductive domains occupy a large volume fraction more than 50 %. Furthermore, POMs can serve as both high proton conductors and nanoenhancers, endowing the bicontinuous nanocomposites with a conductivity of 0.1 mS cm-1 and a Young's modulus of 7.4 GPa at room temperature, which are 2 orders of magnitude and 1.8 times enhanced respectively, compared with the pristine PS-b-P2VP. This approach can provide a new concept based on electrostatic control to design functional bicontinuous polymer materials.

Jinqiang Kuang, Shaista Parveen, Bernhard Breit
Abstract

Rhodium-catalyzed regioselective addition of azlactones to internal alkynes combined with aza-Cope rearrangement provides efficient atom economic access to 2-allyl-3-oxazolin-5-one derivatives. Extension to a triple domino process, in which the above process is combined with in situ azlactone formation starting from amino acids renders this process even more attractive. Subsequent thermolysis of the 2-allyl-3-oxazolines enabled the de novo synthesis of trisubstituted pyridines.

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A triple domino process involving in situ azlactone formation, rhodium-catalyzed alkyne coupling, and aza-Cope rearrangement furnishes useful 2-allyl-3-oxazolin-5-ones in one step. Thermolysis of these products results in pyridines, thereby providing a facile approach to de novo pyridine synthesis.

Journal of the American Chemical Society

Daniel Wendel, Amelie Porzelt, Fabian A. D. Herz, Debotra Sarkar, Christian Jandl, Shigeyoshi Inoue and Bernhard Rieger

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Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b05136
Trevor P. Latendresse, Nattamai S. Bhuvanesh and Michael Nippe

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Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b01499
Souvik Roy, Bhaskar Sharma, Jacques Pécaut, Philippe Simon, Marc Fontecave, Phong D. Tran, Etienne Derat and Vincent Artero
Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b05505

Journal of Physical Chemistry C

Richard Renou, Laurent Soulard, Emilien Lescoute, Corentin Dereure, Didier Loison and Jean-Pierre Guin

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The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.7b01324
Yota Ichinose, Junko Eda, Yohei Yomogida, Zheng Liu and Kazuhiro Yanagi

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The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.7b03896

ACS Nano

Tong Hao, Junjie Li, Fanglian Yao, Dianyu Dong, Yan Wang, Boguang Yang and Changyong Wang

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ACS NanoDOI: 10.1021/acsnano.7b00221
Yujie Ke, Xinglin Wen, Dongyuan Zhao, Renchao Che, Qihua Xiong and Yi Long

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ACS NanoDOI: 10.1021/acsnano.7b02232

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