Nature

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.
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FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing

FTSJ3 is an RNA 2′-<i>O</i>-methyltransferase recruited by HIV to avoid innate immune sensing, Published online: 09 January 2019; doi:10.1038/s41586-018-0841-4

HIV-1 uses the host protein FTSJ3 to methylate its own genome, thereby evading detection by the innate immune system.

Plant-thickening mechanisms revealed

Plant-thickening mechanisms revealed, Published online: 09 January 2019; doi:10.1038/d41586-018-07880-2

In roots, stem cells in the cambium region form vascular tissues needed for the long-distance transport of water and nutrients. How these stem cells are specified and regulated has now been illuminated.

Mitochondrial complex III is essential for suppressive function of regulatory T cells

Mitochondrial complex III is essential for suppressive function of regulatory T cells, Published online: 09 January 2019; doi:10.1038/s41586-018-0846-z

Specific ablation of mitochondrial complex III subunits in Treg cells in mice results in inflammatory disease, altered Treg gene expression and defective Treg function, indicating a key functional role for mitochondrial complex III in Treg cells.

High levels of auxin signalling define the stem-cell organizer of the vascular cambium

High levels of auxin signalling define the stem-cell organizer of the vascular cambium, Published online: 09 January 2019; doi:10.1038/s41586-018-0837-0

In the roots of Arabidopsis thaliana, cells with xylem identity and high levels of auxin signalling function as organizer cells that direct neighbouring vascular cambial cells to act as stem cells.

Announcement: FAIR data in Earth science

Announcement: FAIR data in Earth science, Published online: 09 January 2019; doi:10.1038/d41586-019-00075-3

Nature backs the Enabling FAIR Data initiative and requires authors to deposit data in community repositories.

Black hole goes with the flow

Black hole goes with the flow, Published online: 09 January 2019; doi:10.1038/d41586-019-00011-5

A technique called reverberation mapping has previously been used to probe the structure of matter around supermassive black holes. Observations suggest that this technique can also be applied to much smaller black holes.

A recurrent nova super-remnant in the Andromeda galaxy

A recurrent nova super-remnant in the Andromeda galaxy, Published online: 09 January 2019; doi:10.1038/s41586-018-0825-4

A frequently recurring nova is surrounded by an enormous cavity in space, produced as the nova’s ejecta ‘sweeps up’ the interstellar medium around the star after each eruption.

High-pressure experiments cast light on deep-Earth mineralogy

High-pressure experiments cast light on deep-Earth mineralogy, Published online: 09 January 2019; doi:10.1038/d41586-018-07864-2

A technically challenging analysis has revealed the physical properties of a mineral at pressures and temperatures as high as those in Earth’s mantle. The findings have implications for our understanding of Earth’s deep interior.

Earth’s magnetic field is acting up and geologists don’t know why

Earth’s magnetic field is acting up and geologists don’t know why, Published online: 09 January 2019; doi:10.1038/d41586-019-00007-1

Erratic motion of north magnetic pole forces experts to update model that aids global navigation.

Colombia creates its first science ministry

Colombia creates its first science ministry, Published online: 09 January 2019; doi:10.1038/d41586-019-00087-z

But country-wide structural and cultural changes must occur to truly improve the nation's research environment, scientists say.

Chemical control of structure and guest uptake by a conformationally mobile porous material

Chemical control of structure and guest uptake by a conformationally mobile porous material, Published online: 09 January 2019; doi:10.1038/s41586-018-0820-9

A new metal–organic framework has several conformational degrees of freedom that can be modified by the external chemical environment to change the structure and trigger the uptake of a guest molecule.

Sound velocity of CaSiO3 perovskite suggests the presence of basaltic crust in the Earth’s lower mantle

Sound velocity of CaSiO<sub>3</sub> perovskite suggests the presence of basaltic crust in the Earth’s lower mantle, Published online: 09 January 2019; doi:10.1038/s41586-018-0816-5

In situ high-pressure and high-temperature measurements of the sound velocity of CaSiO3 perovskite suggest accumulation of basaltic crust in the Earth’s uppermost lower mantle.

Designer protein delivers signal of choice

Designer protein delivers signal of choice, Published online: 09 January 2019; doi:10.1038/d41586-018-07883-z

A computational strategy has delivered a redesigned, more stable version of a cytokine protein that mimics the natural protein’s interactions with receptors, opening the way for designer cytokine-based therapeutics.

The corona contracts in a black-hole transient

The corona contracts in a black-hole transient, Published online: 09 January 2019; doi:10.1038/s41586-018-0803-x

X-ray observations of the evolution of a black-hole transient suggest a shrinkage of its corona, rather than a change in the inner edge of the accretion disk.

Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex

Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex, Published online: 09 January 2019; doi:10.1038/s41586-018-0847-y

A subcellular sorting approach enables quantitative analysis of subtypes of growth cones in the brain, and reveals subcellular relationships between local mRNA and local proteomes in developing projection neurons.

De novo design of potent and selective mimics of IL-2 and IL-15

De novo design of potent and selective mimics of IL-2 and IL-15, Published online: 09 January 2019; doi:10.1038/s41586-018-0830-7

A hyper-stable de novo protein mimic of interleukin-2 computationally designed to not interact with a regulatory T-cell specific receptor subunit has improved therapeutic activity in mouse models of melanoma and colon cancer.

Observations of fast radio bursts at frequencies down to 400 megahertz

Observations of fast radio bursts at frequencies down to 400 megahertz, Published online: 09 January 2019; doi:10.1038/s41586-018-0867-7

Observations of fast radio bursts at frequencies down to 400 megahertz

LHX2- and LDB1-mediated trans interactions regulate olfactory receptor choice

LHX2- and LDB1-mediated <i>trans</i> interactions regulate olfactory receptor choice, Published online: 09 January 2019; doi:10.1038/s41586-018-0845-0

Specific interchromosomal contacts in olfactory sensory neurons form a super-enhancer that controls the expression of a single olfactory receptor in each neuron.

Calicivirus VP2 forms a portal-like assembly following receptor engagement

Calicivirus VP2 forms a portal-like assembly following receptor engagement, Published online: 09 January 2019; doi:10.1038/s41586-018-0852-1

Cryo-electron microscopy structures of feline calicivirus and its cellular receptor show that twelve copies of the minor capsid protein VP2 form a portal-like assembly arranged about a pore in the capsid shell.

Threatened UK nuclear-fusion lab secures short-term extension

Threatened UK nuclear-fusion lab secures short-term extension, Published online: 09 January 2019; doi:10.1038/d41586-019-00046-8

The European Union-funded Joint European Torus near Oxford can operate until the end of March, but its future after Brexit is uncertain.

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