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The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.7b05027

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The Journal of Organic ChemistryDOI: 10.1021/acs.joc.7b01129

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ACS NanoDOI: 10.1021/acsnano.7b03109

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Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b05011
Energy & FuelsDOI: 10.1021/acs.energyfuels.7b01721
Energy & FuelsDOI: 10.1021/acs.energyfuels.7b00749
Energy & FuelsDOI: 10.1021/acs.energyfuels.7b00293
Energy & FuelsDOI: 10.1021/acs.energyfuels.7b00222
Lab Chip, 2017, Advance Article
DOI: 10.1039/C7LC90058A, CorrectionOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shang Song, Charles Blaha, Willieford Moses, Jaehyun Park, Nathan Wright, Joey Groszek, William Fissell, Shant Vartanian, Andrew M. Posselt, Shuvo Roy
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Low-density lipoproteins (LDLs) represent a novel class of nanocarriers for the targeted delivery of therapeutics into aberrant cells that overexpress the LDL receptor. Here we report a facile procedure for reconstituting the hydrophobic core of LDLs with a binary fatty acid mixture. Facilitated by the tumor targeting capability of the apolipoprotein, the reconstituted, drug-loaded LDLs can effectively target cancer cells that overexpress the LDL receptor while showing minor adverse impact on normal fibroblasts. According to a hypothesized mechanism, the reconstituted LDLs can also enable metabolism-triggered drug release while preventing the payloads from lysosomal degradation. This study demonstrates that LDLs reconstructed with fatty acids hold great promise to serve as effective and versatile nanocarriers for targeted cancer therapy.

Pd-catalyzed fluoroarylation of gem-difluoroalkenes with aryl halides is disclosed. By taking advantage of the in situ generated α-CF3-benzylsilver intermediates derived from the nucleophilic addition of silver fluoride onto gem-difluoroalkenens, the present strategy bypasses the employment of strong base, thus enabling a mild and general synthetic protocol for the ready access of non-symmetric α,α-disubstituted trifluoroethane derivatives.

A manganese catalyzed regio- and stereoselective hydroarylation of allenes is reported. The C-H functionalization protocol offers access to various alkenylated indoles with excellent yields. Moreover, a hydroarylation/cyclization cascade involving an unexpected C-N bond cleavage and aryl shift has been developed which provides a new synthetic approach to substituted pyrroloindolones.

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MacromoleculesDOI: 10.1021/acs.macromol.7b00954

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Organic LettersDOI: 10.1021/acs.orglett.7b01650

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Chemistry of MaterialsDOI: 10.1021/acs.chemmater.7b00235

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Nano LettersDOI: 10.1021/acs.nanolett.7b01728

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Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b04695

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MacromoleculesDOI: 10.1021/acs.macromol.7b00670

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The Journal of Physical Chemistry ADOI: 10.1021/acs.jpca.7b04161

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MacromoleculesDOI: 10.1021/acs.macromol.7b01035

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